Bottromycins - biosynthesis, synthesis and activity.

Franz, Laura, Kazmaier, Uli, Truman, Andrew W, Koehnke, Jesko

Data Revisão: 08/10/2021
Data Publicação: 23/09/2021 - [DOI: 10.1039/d0np00097c]
JournalNatural Product Reports

Covering: 1950s up to the end of 2020Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a D-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.